Research

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Research

We are engaged in three major areas of research as for new methodologies for catalytic asymmetric synthesis, highly sensitive immunoassay and natural products chemistry.

Development of enantioselective catalysts for carbene transfer and various bond forming reactions:

Fig. 1 Ru(II)-Pheox catalyzed cyclopropanations
Fig.1 Ru(Ⅱ)-Pheox catalyzed
cyclopropanations

These newly designed chiral ligands, a series of chiral bis(oxazolinyl)pyridine and phenyl oxazolines (Pheox) derivatives and their transition metal complexes can be used to efficiently synthesize bioactive organic compounds which are useful for further stereoselective transformations. Especially, Ru(Ⅱ)-Pheox and its microporous polymer supported complex are found to be a powerful chiral catalyst for carbene transfer reactions to synthesize optically active cyclopropane moiety. (Fig.1) We are also pursuing applications of the newly developed methods for the synthesis of biologically relevant molecules.

Development of a monoclonal antibody-based immunoassay

Fig.2 New immunochromatographic assay kits

Fig.2 New immunochromatographic
assay kits

We have developed a enzyme-linked immunosorbent assay(ELISA) system based on a monoclonal antibody (MoA) to detect small toxic molecule such as pesticide in environment, lombining with synthetic organic chemistry and molecular biology. The working range was 0.3 ng/mL level. This device is now commercially available.
Recently, we developed new immunochromatographic assay kits for analyzing pesticide residues in agricultural products. (Fig.2) The kits are useful for inspection of pesticide residues, which have some advantages such as easy handling, simple operation, high sensitivity, high mobility, rapid analysis, and cost effective compare to modern analytical  instruments.

Natural product chemistry

Other areas of our research interests are, natural products chemistry including extraction, purification (Melaleuca essential oil, VN, etc.), and total synthesis of bioactive natural products(DCG-IV, dysibetaine CPa, strychnine etc.), collaborating with southern Asian countries.

Selected Papers:

  • Okazaki, F.; Hirakawa, Y.; Yamaguchi (Murakami), Y.; Harada, A.; Watanabe, E.; Iwasa, S.; Narita, H.; Miyake, S. F. H. S. Sc., 55, [65-72], (2014).
  • Chanthamath, S.; Ozaki, S,; Shibatomi, K.; Iwasa, S. Org. Lett., 16, [3012–3015], (2014).
  • Chanthamath, S.; Chua, H. W.; Kimura, S.; Shibatomi, K.; Iwasa, S. Org. Lett., 16, [3408–3411], (2014).
  • Chanthamath, S.; Takaki, S.; Shibatomi, K.; Iwasa, S. Angew. Chem. Int. Ed., 52, [5930-5933], (2013).
  • Chanthamath, S.; Nguyen, D.; Shibatomi, K.; Iwasa, S., Org. Lett., 15, [772-775], (2013).
  • Abu-Elfotoh, A.-M.; Thi Nguyen, D. P.; Chanthamath, S.; Phomkeona, K.; Shibatomi, K.; Iwasa, S., Adv. Synth. Cat., 354, [3435-3439], (2012).
  • Chanthamath, S.; Phomkeona, K.; Shibatomi, K.; Iwasa, S. Chem. Commun., 48, [7750-7752], (2012).
  • Shibatomi, K.; Soga, Y; Narayama, A; Fujisawa, I; Iwasa, S., Chem. Commun., 48, [7380-7382], (2012).
  • Shibatomi, K.; Soga, Y.; Narayama, A.; Fujisawa, I.; Iwasa, S., J. Am. Chem. Soc. 134, [9836-9839], (2012).
  • Shibatomi, K.; Kobayashi, F.; Narayama, A.; Fujisawa, I.; Iwasa, S., Chem. Commun., 48, [413-415], (2012).
  • Kondo, M.; Tsuzuki, K.; Hamada, H.; Yamaguchi (Murakami), Y.; Uchigashima, M.; Saka, M.; Iwasa, S.; Narita, H.; Miyake, S., J. Agric. Food Chem., 60, [904-911], (2012).

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